業績
論文2001-2005年
2005年
- Kase, S., Nakayama, K.I., Nakayama, K., Ikeda, H., Harada, T., Harada, C., Ohgami, K., Shiratori, K., Ohno, S., Yoshida, K.; Phosphorylation of p27(KIP1) in the developing retina and retinoblastoma. Int. J. Mol. Med. 16, 257-62 (2005).
- Jackson, D., Zheng, Y., Lyo, D., Shen, Y., Nakayama, K., Nakayama, K.I., Humphries, M.J., Reyland, M.E., Foster, D.A.; Suppression of cell migration by protein kinase Cdelta. Oncogene 24, 3067-72 (2005).
- He, C.H., Waxman, A.B., Lee, C.G., Link, H., Rabach, M. E., Ma, B., Chen, Q., Zhu, Z., Zhong, M., Nakayama, K., Nakayama, K.I., Homer, R., Elias, J.A.; Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury. J. Clin. Invest. 115, 1039-48 (2005).
- Jiang, H., Chang, F.-C., Ross, A.E., Lee, J., Nakayama, K.I., Nakayama, K., Desiderio, S.; Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle. Mol. Cell. 18, 699-709 (2005).
- Kotoshiba S., Kamura T., Hara T., Ishida N., Nakayama K.I.; Molecular dissection of the interaction between p27 and KPC, the ubiquitinligase that regulates proteolysis of p27 in G1 phase. J. Biol. Chem. 280, 17694-700 (2005).
- Kase, S., Ikeda, H., Harada, T., Harada, C., Imaki, J., Ohgami, K., Shiratori, K., Nakayama, K.I., Nakayama, K., Ohno, S., Yoshida, K.; Disappearance of p27(KIP1) and increase in proliferation of the lens cells after extraction of most of the fiber cells of the lens. Curr. Eye Res. 30, 437-42 (2005).
- Rodier, G., Makris, C., Coulombe, P., Scime, A., Nakayama, K., Nakayama, K.I., Meloche, S.; p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2. J. Cell Biol. 168, 55-66 (2005).
- Kotake, Y., Nakayama, K., Ishida, N., Nakayama, K.I.; Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation. J. Biol. Chem. 280, 1095-102 (2005).
2004年
- Nakayama, K., Nagahama, H., Minamishima, Y.A., Miyake, S., Ishida, N., Hatakeyama, S., Kitagawa, M., Iemura, S., Natsume, T., Nakayama, K.I.; Skp2-mediated degradation of p27 regulates progression into mitosis. Dev. Cell 6, 661-72 (2004).
- Kamura, T., Hara, T., Matsumoto, M., Ishida, N., Okumura, F., Hatakeyama, S., Yoshida, M., Nakayama, K., Nakayama, K.I.; Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27Kip1 at G1 phase. Nature Cell Biol. 6, 1229-35 (2004).
- Tokarz, S.A., Berset, C., La Rue, J.M., Friedman, K., Nakayama, K.I., Nakayama, K., Zhang, D.E., Lanker, S.; The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCF(Skp2) ubiquitin ligase. J. Biol. Chem. 279, 46424-30 (2004).
- Nishiyama, M., Nakayama, K., Tsunematsu, R., Tsukiyama, T., Kikuchi, A., Nakayama, K.I.; Early embryonic death in mice lacking the beta-catenin-binding protein Duplin. Mol. Cell. Biol. 24, 8386-94 (2004).
- Li, B., Wang, X., Rasheed, N., Hu, Y., Boast, S., Ishii, T., Nakayama, K., Nakayama, K.I., Goff, S.P.; Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C delta. Genes Dev. 18, 1824-37 (2004).
- Yoshida, K., Kase, S., Nakayama, K., Nagahama, H., Harada, T., Ikeda, H., Harada, C., Imaki, J., Ohgami, K., Shiratori, K., Ilieva, I.B., Ohno, S., Nishi, S., Nakayama, K.I.; Involvement of p27KIP1 in the proliferation of the developing corneal endothelium. Invest. Ophthalmol. Vis. Sci. 45, 2163-7 (2004).
- Oh, K.J., Kalinina, A., Wang, J., Nakayama, K., Nakayama, K.I., Bagchi, S.; The papillomavirus E7 oncoprotein is ubiquitinated by UbcH7 and Cullin 1- and Skp2-containing E3 ligase. J. Virol. 78, 5338-46 (2004).
- Yoshida, K., Nakayama, K., Kase, S., Nagahama, H., Harada, T., Ikeda, H., Harada, C., Imaki, J., Ohgami, K., Shiratori, K., Ohno, S., Nishi, S., Nakayama, K.I.; Involvement of p27(KIP1) in proliferation of the retinal pigment epithelium and ciliary body. Anat. Embryol. 208, 145-50 (2004).
- Yoshida, K., Kase, S., Nakayama, K., Nagahama, H., Harada, T., Ikeda, H., Harada, C., Imaki, J., Ohgami, K., Shiratori, K., Ohno, S., Nakayama, K.I.; Distribution of p27(KIP1), cyclin D1, and proliferating cell nuclear antigen after retinal detachment. Graefes Arch. Clin. Exp. Ophthalmol. 242, 437-41 (2004).
- Yada, M., Hatakeyama, S., Kamura, T., Nishiyama, M., Tsunematsu, R., Imaki, H., Ishida, N., Okumura, F., Nakayama, K., Nakayama, K.I.; Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J. 23, 2116-25 (2004).
- Tsunematsu, R., Nakayama, K., Oike, Y., Nishiyama, M., Ishida, N., Hatakeyama, S., Bessho, Y., Kageyama, R., Suda, T., Nakayama, K.I.; Mouse Fbw7/Sel-10/Cdc4 is required for Notch degradation during vascular development. J. Biol. Chem. 279, 9417-23 (2004).
2003年
- Chang, T.S., Kim, M.J., Ryoo, K., Park, J., Eom, S.J., Shim, J., Nakayama, K.I., Nakayama, K., Tomita, M., Takahashi, K., Lee, M. J., Choi, E. J.; p57KIP2 modulates stress-activated signaling by inhibiting c-Jun NH2-terminal kinase/stress-activated protein Kinase. J. Biol. Chem. 278, 48092-8 (2003).
- Kamura, T., Hara, T., Kotoshiba, S., Yada, M., Ishida, N., Imaki, H., Hatakeyama, S., Nakayama, K., Nakayama, K.I.; Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation. Proc. Natl. Acad. Sci. U S A 100, 10231-6 (2003).
- Imaki, H., Nakayama, K., Delehouzee, S., Handa, H., Kitagawa, M., Kamura, T., Nakayama, K.I.; Cell cycle-dependent regulation of the Skp2 promoter by GA-binding protein. Cancer Res. 63, 4607-13 (2003).
- Nakayama, K., Hatakeyama, S., Maruyama, S., Kikuchi, A., Onoe, K., Good, R. A., Nakayama, K.I.; Impaired degradation of inhibitory subunit of NF-kappa B (I kappa B) and beta-catenin as a result of targeted disruption of the beta-TrCP1 gene. Proc. Natl. Acad. Sci. U S A 100, 8752-7 (2003).
- Watahiki, J., Yamaguchi, T., Irie, T., Takahashi, K., Nakano, H., Yagasaki, Y., Nakayama, K.I., Nakayama, K., Maki, K., Tachikawa, T.; The role of p57Kip2 on mandibular growth in mice: By means of laser microdissection for hard tissues. Orthod. Waves 62, 201-206 (2003).
- von der Lehr, N., Johansson, S., Wu, S., Bahram, F., Castell, A., Cetinkaya, C., Hydbring, P., Weidung, I., Nakayama, K., Nakayama, K.I., Soderberg, O., Kerppola, T.K., Larsson, L.G.; The F-Box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription. Mol. Cell 11, 1189-200 (2003).
- Bornstein, G., Bloom, J., Sitry-Shevah, D., Nakayama, K., Pagano, M., Hershko, A.; Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase. J. Biol. Chem. 278, 25752-7 (2003).
- Zhang, Y.W., Nakayama, K., Nakayama, K.I., Morita, I.; A novel route for connexin 43 to inhibit cell proliferation: negative regulation of S-phase kinase-associated protein (Skp 2). Cancer Res. 63, 1623-30 (2003).
- Kaneko, C., Hatakeyama, S., Matsumoto, M., Yada, M., Nakayama, K., Nakayama, K.I.; Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a. Biochem. Biophys. Res. Commun. 300, 297-304 (2003).
- Tsukuba, T., Okamoto, K., Okamoto, Y., Yanagawa, M., Kohmura, K., Yasuda, Y., Uchi, H., Nakahara, T., Furue, M., Nakayama, K., Kadowaki, T., Yamamoto, K., Nakayama, K.I.; Association of cathepsin e deficiency with development of atopic dermatitis. J. Biochem. 134, 893-902 (2003).
- Foster, S.J., Fernando, I.R., Ishida, N., Nakayama, K.I., Wimalasena, J.; Estrogens down-regulate p27Kip1 in brest cancer cells through SKP2, and through nuclear export mediated by the extracellular signal-regulated kinase (Erk1) pathway. J. Biol. Chem. 278, 41355-66 (2003).
2002年
- Matsuura, T., Takahashi, K., Nakayama, K., Kobayashi, T., Choi-Miura, N. H., Tomita, M., Kanayama, N.; Increased expression of vascular endothelial growth factor in placentas of p57(Kip2) null embryos. FEBS Lett. 532, 283-8 (2002).
- Kanayama, N., Takahashi, K., Matsuura, T., Sugimura, M., Kobayashi, T., Moniwa, N., Tomita, M., Nakayama, K.; Deficiency in p57Kip2 expression induces preeclampsia-like symptoms in mice. Mol. Hum. Reprod. 8, 1129-35 (2002).
- Tomari, S., Nagahama, H., Shu, Y., Hoshi, S., Nakayama, K., Nakayama, K.I., Nagata, M.; Glomerular differentiation in p27 and p57 double-mutant metanephroi. Anat. Embryol. 206, 31-6 (2002).
- Garcia-Fernandez, L.F., Losada, A., Alcaide, V., Alvarez, A. M., Cuadrado, A., Gonzalez, L., Nakayama, K., Nakayama, K.I., Fernandez-Sousa, J.M., Munoz, A., Sanchez-Puelles, J.M.; Aplidin induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C delta. Oncogene 21, 7533-44 (2002).
- Masuda, T.A., Inoue, H., Sonoda, H., Mine, S., Yoshikawa, Y., Nakayama, K., Nakayama, K.I., Mori, M.; Clinical and biological significance of S-phase kinase-associated protein 2 (Skp2) gene expression in gastric carcinoma: modulation of malignant phenotype by Skp2 overexpression, possibly via p27 proteolysis. Cancer Res. 62, 3819-25 (2002).
- Ishida, N., Hara, T., Kamura, T., Yoshida, M., Nakayama, K., Nakayama, K.I.; Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export. J. Biol. Chem. 277, 14355-8 (2002).
- Miyamoto, A., Nakayama, K., Imaki, H., Hirose, S., Jiang, Y., Abe, M., Tsukiyama, T., Nagahama, H., Ohno, S., Hatakeyama, S., Nakayama, K.I.; Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature 416, 865-9 (2002).
- Kanematsu, T., Jang, I. S., Yamaguchi, T., Nagahama, H., Yoshimura, K., Hidaka, K., Matsuda, M., Takeuchi, H., Misumi, Y., Nakayama, K., Yamamoto, T., Akaike, N., Hirata, M., Nakayama, K.I.; Role of the PLC-related, catalytically inactive protein p130 in GABA(A) receptor function. EMBO J. 21, 1004-1011 (2002).
- Minamishima, Y.A., Nakayama, K., Nakayama, K.I.; Recovery of liver mass without proliferation of hepatocytes after partial hepatectomy in Skp2-deficient mice. Cancer Res. 62, 995-9 (2002).
- Yoshida, K., Nakayama, K., Nagahama, H., Harada, T., Harada, C., Imaki, J., Matsuda, A., Yamamoto, K., Ito, M., Ohno, S., Nakayama, K.I.; Involvement of p27(KIP1) degradation by Skp2 in the regulation of proliferation in response to wounding of corneal epithelium. Invest. Ophthalmol. Vis. Sci. 43, 364-70 (2002).
2001年
- Hara, T., Kamura, T., Nakayama, K., Oshikawa, K., Hatakeyama, S., Nakayama, K.I.; Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway. J. Biol. Chem. 276, 48937-43. (2001).
- Doira, N., Kanematsu, T., Matsuda, M., Takeuchi, H., Nakano, H., Ito, Y., Nakayama, K., Nakayama, K.I., Hirata, M.; Hyperinsulinemia in PRIP-1 gene deleted mice. Biomed. Res. 22, 157-165 (2001).
- Kiernan, R.E., Emiliani, S., Nakayama, K., Castro, A., Labbe, J. C., Lorca, T., Nakayama, K.I., Benkirane, M.; Interaction between cyclin T1 and SCFSKP2 targets CDK9 for ubiquitination and degradation by the proteasome. Mol. Cell. Biol. 21, 7956-70 (2001).
- Maruyama, S., Hatakeyama, S., Nakayama, K., Ishida, N., Kawakami, K., Nakayama, K.I.; Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10. Genomics 78, 214-222 (2001).
- Ikeda, H., Yoshimoto, T., Shida, N., Miyoshi, I., Nakayama, K., Nakayama, K.I., Oshima, M., Taketo, M.M.; Morphologic and molecular analysis of estrogen-induced pituitary tumorigenesis in targeted disruption of transforming growth factor-beta receptor type II and/or p27 mice. Endocrine 16, 55-65 (2001).
- Malek, N.P., Sundberg, H., McGrew, S., Nakayama, K., Kyriakidis, T.R., Roberts, J.M.; A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase. Nature 413, 323-7 (2001).
- Morishita, H., Makishima, T., Kaneko, C., Lee, Y. S., Segil, N., Takahashi, K., Kuraoka, A., Nakagawa, T., Nabekura, J., Nakayama, K., Nakayama, K.I.; Deafness due to degeneration of cochlear neurons in caspase-3-deficient mice. Biochem. Biophys. Res. Commun. 284, 142-9 (2001).
- Nagahama, H., Hatakeyama, S., Nakayama, K., Nagata, M., Tomita, K., Nakayama, K.I.; Spatial and temporal expression patterns of the cyclin-dependent kinase (CDK) inhibitors p27Kip1 and p57Kip2 during mouse development. Anat. Embryol. 203, 77-87 (2001).
- Tsukiyama, T., Ishida, N., Shirane, M., Minamishima, Y.A., Hatakeyama, S., Kitagawa, M., Nakayama, K., Nakayama, K.I.; Down-regulation of p27(Kip1) expression is required for development and function of T cells. J. Immunol. 166, 304-312 (2001).
- Hatakeyama, S., Yada, M., Matsumoto, M., Ishida, N., Nakayama, K.I.; U box proteins as a new family of ubiquitin-protein ligases. J. Biol. Chem. 276, 33111-20 (2001).