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業績

論文2001-2005年

2005年

  1. Kase, S., Nakayama, K.I., Nakayama, K., Ikeda, H., Harada, T., Harada, C., Ohgami, K., Shiratori, K., Ohno, S., Yoshida, K.; Phosphorylation of p27(KIP1) in the developing retina and retinoblastoma. Int. J. Mol. Med. 16, 257-62 (2005).
  2. Jackson, D., Zheng, Y., Lyo, D., Shen, Y., Nakayama, K., Nakayama, K.I., Humphries, M.J., Reyland, M.E., Foster, D.A.; Suppression of cell migration by protein kinase Cdelta. Oncogene 24, 3067-72 (2005).
  3. He, C.H., Waxman, A.B., Lee, C.G., Link, H., Rabach, M. E., Ma, B., Chen, Q., Zhu, Z., Zhong, M., Nakayama, K., Nakayama, K.I., Homer, R., Elias, J.A.; Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury. J. Clin. Invest. 115, 1039-48 (2005).
  4. Jiang, H., Chang, F.-C., Ross, A.E., Lee, J., Nakayama, K.I., Nakayama, K., Desiderio, S.; Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle. Mol. Cell. 18, 699-709 (2005).
  5. Kotoshiba S., Kamura T., Hara T., Ishida N., Nakayama K.I.; Molecular dissection of the interaction between p27 and KPC, the ubiquitinligase that regulates proteolysis of p27 in G1 phase. J. Biol. Chem. 280, 17694-700 (2005).
  6. Kase, S., Ikeda, H., Harada, T., Harada, C., Imaki, J., Ohgami, K., Shiratori, K., Nakayama, K.I., Nakayama, K., Ohno, S., Yoshida, K.; Disappearance of p27(KIP1) and increase in proliferation of the lens cells after extraction of most of the fiber cells of the lens. Curr. Eye Res. 30, 437-42 (2005).
  7. Rodier, G., Makris, C., Coulombe, P., Scime, A., Nakayama, K., Nakayama, K.I., Meloche, S.; p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2. J. Cell Biol. 168, 55-66 (2005).
  8. Kotake, Y., Nakayama, K., Ishida, N., Nakayama, K.I.; Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation. J. Biol. Chem. 280, 1095-102 (2005).

2004年

  1. Nakayama, K., Nagahama, H., Minamishima, Y.A., Miyake, S., Ishida, N., Hatakeyama, S., Kitagawa, M., Iemura, S., Natsume, T., Nakayama, K.I.; Skp2-mediated degradation of p27 regulates progression into mitosis. Dev. Cell 6, 661-72 (2004).
  2. Kamura, T., Hara, T., Matsumoto, M., Ishida, N., Okumura, F., Hatakeyama, S., Yoshida, M., Nakayama, K., Nakayama, K.I.; Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27Kip1 at G1 phase. Nature Cell Biol. 6, 1229-35 (2004).
  3. Tokarz, S.A., Berset, C., La Rue, J.M., Friedman, K., Nakayama, K.I., Nakayama, K., Zhang, D.E., Lanker, S.; The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCF(Skp2) ubiquitin ligase. J. Biol. Chem. 279, 46424-30 (2004).
  4. Nishiyama, M., Nakayama, K., Tsunematsu, R., Tsukiyama, T., Kikuchi, A., Nakayama, K.I.; Early embryonic death in mice lacking the beta-catenin-binding protein Duplin. Mol. Cell. Biol. 24, 8386-94 (2004).
  5. Li, B., Wang, X., Rasheed, N., Hu, Y., Boast, S., Ishii, T., Nakayama, K., Nakayama, K.I., Goff, S.P.; Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C delta. Genes Dev. 18, 1824-37 (2004).
  6. Yoshida, K., Kase, S., Nakayama, K., Nagahama, H., Harada, T., Ikeda, H., Harada, C., Imaki, J., Ohgami, K., Shiratori, K., Ilieva, I.B., Ohno, S., Nishi, S., Nakayama, K.I.; Involvement of p27KIP1 in the proliferation of the developing corneal endothelium. Invest. Ophthalmol. Vis. Sci. 45, 2163-7 (2004).
  7. Oh, K.J., Kalinina, A., Wang, J., Nakayama, K., Nakayama, K.I., Bagchi, S.; The papillomavirus E7 oncoprotein is ubiquitinated by UbcH7 and Cullin 1- and Skp2-containing E3 ligase. J. Virol. 78, 5338-46 (2004).
  8. Yoshida, K., Nakayama, K., Kase, S., Nagahama, H., Harada, T., Ikeda, H., Harada, C., Imaki, J., Ohgami, K., Shiratori, K., Ohno, S., Nishi, S., Nakayama, K.I.; Involvement of p27(KIP1) in proliferation of the retinal pigment epithelium and ciliary body. Anat. Embryol. 208, 145-50 (2004).
  9. Yoshida, K., Kase, S., Nakayama, K., Nagahama, H., Harada, T., Ikeda, H., Harada, C., Imaki, J., Ohgami, K., Shiratori, K., Ohno, S., Nakayama, K.I.; Distribution of p27(KIP1), cyclin D1, and proliferating cell nuclear antigen after retinal detachment. Graefes Arch. Clin. Exp. Ophthalmol. 242, 437-41 (2004).
  10. Yada, M., Hatakeyama, S., Kamura, T., Nishiyama, M., Tsunematsu, R., Imaki, H., Ishida, N., Okumura, F., Nakayama, K., Nakayama, K.I.; Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J. 23, 2116-25 (2004).
  11. Tsunematsu, R., Nakayama, K., Oike, Y., Nishiyama, M., Ishida, N., Hatakeyama, S., Bessho, Y., Kageyama, R., Suda, T., Nakayama, K.I.; Mouse Fbw7/Sel-10/Cdc4 is required for Notch degradation during vascular development. J. Biol. Chem. 279, 9417-23 (2004).

2003年

  1. Chang, T.S., Kim, M.J., Ryoo, K., Park, J., Eom, S.J., Shim, J., Nakayama, K.I., Nakayama, K., Tomita, M., Takahashi, K., Lee, M. J., Choi, E. J.; p57KIP2 modulates stress-activated signaling by inhibiting c-Jun NH2-terminal kinase/stress-activated protein Kinase. J. Biol. Chem. 278, 48092-8 (2003).
  2. Kamura, T., Hara, T., Kotoshiba, S., Yada, M., Ishida, N., Imaki, H., Hatakeyama, S., Nakayama, K., Nakayama, K.I.; Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation. Proc. Natl. Acad. Sci. U S A 100, 10231-6 (2003).
  3. Imaki, H., Nakayama, K., Delehouzee, S., Handa, H., Kitagawa, M., Kamura, T., Nakayama, K.I.; Cell cycle-dependent regulation of the Skp2 promoter by GA-binding protein. Cancer Res. 63, 4607-13 (2003).
  4. Nakayama, K., Hatakeyama, S., Maruyama, S., Kikuchi, A., Onoe, K., Good, R. A., Nakayama, K.I.; Impaired degradation of inhibitory subunit of NF-kappa B (I kappa B) and beta-catenin as a result of targeted disruption of the beta-TrCP1 gene. Proc. Natl. Acad. Sci. U S A 100, 8752-7 (2003).
  5. Watahiki, J., Yamaguchi, T., Irie, T., Takahashi, K., Nakano, H., Yagasaki, Y., Nakayama, K.I., Nakayama, K., Maki, K., Tachikawa, T.; The role of p57Kip2 on mandibular growth in mice: By means of laser microdissection for hard tissues. Orthod. Waves 62, 201-206 (2003).
  6. von der Lehr, N., Johansson, S., Wu, S., Bahram, F., Castell, A., Cetinkaya, C., Hydbring, P., Weidung, I., Nakayama, K., Nakayama, K.I., Soderberg, O., Kerppola, T.K., Larsson, L.G.; The F-Box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription. Mol. Cell 11, 1189-200 (2003).
  7. Bornstein, G., Bloom, J., Sitry-Shevah, D., Nakayama, K., Pagano, M., Hershko, A.; Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase. J. Biol. Chem. 278, 25752-7 (2003).
  8. Zhang, Y.W., Nakayama, K., Nakayama, K.I., Morita, I.; A novel route for connexin 43 to inhibit cell proliferation: negative regulation of S-phase kinase-associated protein (Skp 2). Cancer Res. 63, 1623-30 (2003).
  9. Kaneko, C., Hatakeyama, S., Matsumoto, M., Yada, M., Nakayama, K., Nakayama, K.I.; Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a. Biochem. Biophys. Res. Commun. 300, 297-304 (2003).
  10. Tsukuba, T., Okamoto, K., Okamoto, Y., Yanagawa, M., Kohmura, K., Yasuda, Y., Uchi, H., Nakahara, T., Furue, M., Nakayama, K., Kadowaki, T., Yamamoto, K., Nakayama, K.I.; Association of cathepsin e deficiency with development of atopic dermatitis. J. Biochem. 134, 893-902 (2003).
  11. Foster, S.J., Fernando, I.R., Ishida, N., Nakayama, K.I., Wimalasena, J.; Estrogens down-regulate p27Kip1 in brest cancer cells through SKP2, and through nuclear export mediated by the extracellular signal-regulated kinase (Erk1) pathway. J. Biol. Chem. 278, 41355-66 (2003).

2002年

  1. Matsuura, T., Takahashi, K., Nakayama, K., Kobayashi, T., Choi-Miura, N. H., Tomita, M., Kanayama, N.; Increased expression of vascular endothelial growth factor in placentas of p57(Kip2) null embryos. FEBS Lett. 532, 283-8 (2002).
  2. Kanayama, N., Takahashi, K., Matsuura, T., Sugimura, M., Kobayashi, T., Moniwa, N., Tomita, M., Nakayama, K.; Deficiency in p57Kip2 expression induces preeclampsia-like symptoms in mice. Mol. Hum. Reprod. 8, 1129-35 (2002).
  3. Tomari, S., Nagahama, H., Shu, Y., Hoshi, S., Nakayama, K., Nakayama, K.I., Nagata, M.; Glomerular differentiation in p27 and p57 double-mutant metanephroi. Anat. Embryol. 206, 31-6 (2002).
  4. Garcia-Fernandez, L.F., Losada, A., Alcaide, V., Alvarez, A. M., Cuadrado, A., Gonzalez, L., Nakayama, K., Nakayama, K.I., Fernandez-Sousa, J.M., Munoz, A., Sanchez-Puelles, J.M.; Aplidin induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C delta. Oncogene 21, 7533-44 (2002).
  5. Masuda, T.A., Inoue, H., Sonoda, H., Mine, S., Yoshikawa, Y., Nakayama, K., Nakayama, K.I., Mori, M.; Clinical and biological significance of S-phase kinase-associated protein 2 (Skp2) gene expression in gastric carcinoma: modulation of malignant phenotype by Skp2 overexpression, possibly via p27 proteolysis. Cancer Res. 62, 3819-25 (2002).
  6. Ishida, N., Hara, T., Kamura, T., Yoshida, M., Nakayama, K., Nakayama, K.I.; Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export. J. Biol. Chem. 277, 14355-8 (2002).
  7. Miyamoto, A., Nakayama, K., Imaki, H., Hirose, S., Jiang, Y., Abe, M., Tsukiyama, T., Nagahama, H., Ohno, S., Hatakeyama, S., Nakayama, K.I.; Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature 416, 865-9 (2002).
  8. Kanematsu, T., Jang, I. S., Yamaguchi, T., Nagahama, H., Yoshimura, K., Hidaka, K., Matsuda, M., Takeuchi, H., Misumi, Y., Nakayama, K., Yamamoto, T., Akaike, N., Hirata, M., Nakayama, K.I.; Role of the PLC-related, catalytically inactive protein p130 in GABA(A) receptor function. EMBO J. 21, 1004-1011 (2002).
  9. Minamishima, Y.A., Nakayama, K., Nakayama, K.I.; Recovery of liver mass without proliferation of hepatocytes after partial hepatectomy in Skp2-deficient mice. Cancer Res. 62, 995-9 (2002).
  10. Yoshida, K., Nakayama, K., Nagahama, H., Harada, T., Harada, C., Imaki, J., Matsuda, A., Yamamoto, K., Ito, M., Ohno, S., Nakayama, K.I.; Involvement of p27(KIP1) degradation by Skp2 in the regulation of proliferation in response to wounding of corneal epithelium. Invest. Ophthalmol. Vis. Sci. 43, 364-70 (2002).

2001年

  1. Hara, T., Kamura, T., Nakayama, K., Oshikawa, K., Hatakeyama, S., Nakayama, K.I.; Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway. J. Biol. Chem. 276, 48937-43. (2001).
  2. Doira, N., Kanematsu, T., Matsuda, M., Takeuchi, H., Nakano, H., Ito, Y., Nakayama, K., Nakayama, K.I., Hirata, M.; Hyperinsulinemia in PRIP-1 gene deleted mice. Biomed. Res. 22, 157-165 (2001).
  3. Kiernan, R.E., Emiliani, S., Nakayama, K., Castro, A., Labbe, J. C., Lorca, T., Nakayama, K.I., Benkirane, M.; Interaction between cyclin T1 and SCFSKP2 targets CDK9 for ubiquitination and degradation by the proteasome. Mol. Cell. Biol. 21, 7956-70 (2001).
  4. Maruyama, S., Hatakeyama, S., Nakayama, K., Ishida, N., Kawakami, K., Nakayama, K.I.; Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10. Genomics 78, 214-222 (2001).
  5. Ikeda, H., Yoshimoto, T., Shida, N., Miyoshi, I., Nakayama, K., Nakayama, K.I., Oshima, M., Taketo, M.M.; Morphologic and molecular analysis of estrogen-induced pituitary tumorigenesis in targeted disruption of transforming growth factor-beta receptor type II and/or p27 mice. Endocrine 16, 55-65 (2001).
  6. Malek, N.P., Sundberg, H., McGrew, S., Nakayama, K., Kyriakidis, T.R., Roberts, J.M.; A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase. Nature 413, 323-7 (2001).
  7. Morishita, H., Makishima, T., Kaneko, C., Lee, Y. S., Segil, N., Takahashi, K., Kuraoka, A., Nakagawa, T., Nabekura, J., Nakayama, K., Nakayama, K.I.; Deafness due to degeneration of cochlear neurons in caspase-3-deficient mice. Biochem. Biophys. Res. Commun. 284, 142-9 (2001).
  8. Nagahama, H., Hatakeyama, S., Nakayama, K., Nagata, M., Tomita, K., Nakayama, K.I.; Spatial and temporal expression patterns of the cyclin-dependent kinase (CDK) inhibitors p27Kip1 and p57Kip2 during mouse development. Anat. Embryol. 203, 77-87 (2001).
  9. Tsukiyama, T., Ishida, N., Shirane, M., Minamishima, Y.A., Hatakeyama, S., Kitagawa, M., Nakayama, K., Nakayama, K.I.; Down-regulation of p27(Kip1) expression is required for development and function of T cells. J. Immunol. 166, 304-312 (2001).
  10. Hatakeyama, S., Yada, M., Matsumoto, M., Ishida, N., Nakayama, K.I.; U box proteins as a new family of ubiquitin-protein ligases. J. Biol. Chem. 276, 33111-20 (2001).