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業績

論文2000年以前

2000年

  1. Shimoda, K., Kato, K., Aoki, K., Matsuda, T., Miyamoto, A., Shibamori, M., Yamashita, M., Numata, A., Takase, K., Kobayashi, S., Shibata, S., Asano, Y., Gondo, H., Sekiguchi, K., Nakayama, K., Nakayama, T., Okamura, T., Okamura, S., Niho, Y., Nakayama, K.I.; Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function. Immunity 13, 561-571 (2000).
  2. Kitagawa, K., Kawamoto, T., Kunugita, N., Tsukiyama, T., Okamoto, K., Yoshida, A., Nakayama, K., Nakayama, K.I.; Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse. FEBS Lett. 476, 306-311 (2000).
  3. Takai, H., Tominaga, K., Motoyama, N., Minamishima, Y.A., Nagahama, H., Tsukiyama, T., Ikeda, K., Nakayama, K., Nakanishi, N., Nakayama, K.I.; Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice. Genes. Dev. 14, 1439-1447 (2000).
  4. Nakayama, K., Nagahama, H., Minamishima, Y.A., Matsumoto, M., Nakamichi, I., Kitagawa, K., Shirane, M., Tsunematsu, R., Tsukiyama, T., Ishida, N., Kitagawa, M., Nakayama, K.I., Hatakeyama, S.; Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J. 19, 2069-2081 (2000).
  5. Takahashi, K., Nakayama, K.I., Nakayama, K.; Mice lacking a CDK inhibitor, p57(Kip2), exhibit skeletal abnormalities and growth retardation. J. Biochem. 127, 73-83 (2000).
  6. Ishida, N., Kitagawa, M., Hatakeyama, S., Nakayama, K.I.; Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability. J. Biol. Chem. 275, 25146-54 (2000).
  7. Ishida, K.I., Ishida, N., Hara, Y.; Lotharella amoeboformis sp. nov.: a new species of chlorarachniophytes from Japan. Phycol. Res. 48, 221-9 (2000).

1999年

  1. Shirane, M., Hatakeyama, S., Hattori, K., Nakayama, K., Nakayama, K.I.; Common pathway for the ubiquitination of I kappa B alpha, I kappa B beta, and I kappa B epsilon mediated by the F-box protein FWD1. J. Biol. Chem. 274, 28169-28174 (1999).
  2. Kitagawa, M., Hatakeyama, S., Shirane, M., Matsumoto, M., Ishida, N., Hattori, K., Nakamichi, I., Kikuchi, A., Nakayama, K.I., Nakayama, K.; An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin. EMBO J. 18, 2401-10 (1999).
  3. Hatakeyama, S., Kitagawa, M., Nakayama, K., Shirane, M., Matsumoto, M., Hattori, K., Higashi, H., Nakano, H., Okumura, K., Onoe, K., Good, R. A., Nakayama, K.I.; Ubiquitin-dependent degradation of I kappa B alpha is mediated by a ubiquitin ligase Skp1/Cul1/F-box protein FWD1. Proc. Natl. Acad. Sci. U S A 96, 3859-3863 (1999).

1998年

  1. Hamasaki, A., Sendo, F., Nakayama, K., Ishida, N., Negishi, I., Nakayama, K.I., Hatakeyama, S.; Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene. J. Exp. Med. 188, 1985-1992 (1998).
  2. Hatakeyama, S., Hamasaki, A., Negishi, I., Loh, D. Y., Sendo, F., Nakayama, K., Nakayama, K.I.; Multiple gene duplication and expression of mouse bcl-2-related genes, A1. Int. Immunol. 10, 631-637 (1998)

1997年

  1. Matsuzaki, Y., Nakayama, K.I., Nakayama, K., Tomita, T., Isoda, M., Loh, D. Y., Nakauchi, H.; Role of bcl-2 in the development of lymphoid cells from the hematopoietic stem cell. Blood 89, 853-62 (1997).

1996年

  1. Nagata, M., Nakauchi, H., Nakayama, K.I., Nakayama, K., Loh, D., Watanabe, T.; Apoptosis during an early stage of nephrogenesis induces renal hypoplasia in bcl-2-deficient mice. Am. J. Pathol. 148, 1601-11 (1996).
  2. Senju, S., Negishi, I., Motoyama, N., Wang, F., Nakayama, K.I., Nakayama, K., Lucas, P.J., Hatakeyama, S., Zhang, Q., Yonehara, S., Loh, D.Y.; Functional significance of the Fas molecule in naive lymphocytes. Int. Immunol. 8, 423-31 (1996).
  3. Nakayama, K., Ishida, N., Shirane, M., Inomata, A., Inoue, T., Shishido, N., Horii, I., Loh, D.Y., Nakayama, K.I.; Mice lacking p27Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 85, 707-20 (1996).

1995年

  1. Nakayama, K.I., Nakayama, K., Dustin, L.B., Loh, D.Y.; T-B cell interaction inhibits spontaneous apoptosis of mature lymphocytes in Bcl-2-deficient mice. J. Exp. Med. 182, 1101-9 (1995).
  2. Merritt, A.J., Potten, C.S., Watson, A.J., Loh, D.Y., Nakayama, K.I., Nakayama, K., Hickman, J. A.; Differential expression of bcl-2 in intestinal epithelia. Correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia. J. Cell. Sci. 108, 2261-71 (1995).
  3. Negishi, I., Motoyama, N., Nakayama, K.I., Nakayama, K., Senju, S., Hatakeyama, S., Zhang, Q., Chan, A.C., Loh, D.Y.; Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature 376, 435-8 (1995).
  4. Motoyama, N., Wang, F., Roth, K. A., Sawa, H., Nakayama, K.I., Nakayama, K., Negishi, I., Senju, S., Zhang, Q., Fujii, S., Loh, D.Y.; Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science 267, 1506-10 (1995).

1994年

  1. Nakayama, K., Nakayama, K.I., Negishi, I., Kuida, K., Sawa, H., Loh, D.Y.; Targeted disruption of Bcl-2 ab in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia. Proc. Natl. Acad. Sci. U S A 91, 3700-4 (1994).
  2. Nakayama, K.I., Nakayama, K., Negishi, I., Kuida, K., Louie, M.C., Kanagawa, O., Nakauchi, H., Loh, D.Y.; Requirement for CD8 b chain in positive selection of CD8-lineage T cells. Science 263, 1131-3 (1994).

1993年

  1. Nakayama, K.I., Nakayama, K., Negishi, I., Kuida, K., Shinkai, Y., Louie, M.C., Fields, L.E., Lucas, P.J., Stewart, V., Alt, F.W., Loh, D.Y.; Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice. Science 261, 1584-8 (1993).
  2. Hiraoka, M., Fan, Z., Furukawa, T., Nakayama, K., Sawanobori, T.; Activation and reactivation of the ATP-sensitive K+ channel of the heart can be modified by drugs. Cardiovasc. Drugs. Ther. 7, 593-8 (1993).

1992年

  1. Fan, Z., Nakayama, K., Sawanobori, T., Hiraoka, M.; Aromatic aldehydes and aromatic ketones open ATP-sensitive K+ channels in guinea-pig ventricular myocytes. Pflugers Arch. 421, 409-15 (1992).

1991年

  1. Nakayama, K., Fan, Z., Marumo, F., Sawanobori, T., Hiraoka, M.; Action of nicorandil on ATP-sensitive K+ channel in guinea-pig ventricular myocytes. Br. J. Pharmacol. 103, 1641-8 (1991).

1990年

  1. Fan, Z., Nakayama, K., Hiraoka, M.; Multiple actions of pinacidil on adenosine triphosphate-sensitive potassium channels in guinea-pig ventricular myocytes. J. Physiol. (Lond.) 430, 273-95 (1990).
  2. Nakayama, K., Fan, Z., Marumo, F., Hiraoka, M.; Interrelation between pinacidil and intracellular ATP concentrations on activation of the ATP-sensitive K+ current in guinea pig ventricular myocytes. Circ. Res. 67, 1124-33 (1990).
  3. Fan, Z., Nakayama, K., Hiraoka, M.; Pinacidil activates the ATP-sensitive K+ channel in inside-out and cell-attached patch membranes of guinea-pig ventricular myocytes. Pflugers Arch. 415, 387-94 (1990).