業績
論文2000年以前
2000年
- Shimoda, K., Kato, K., Aoki, K., Matsuda, T., Miyamoto, A., Shibamori, M., Yamashita, M., Numata, A., Takase, K., Kobayashi, S., Shibata, S., Asano, Y., Gondo, H., Sekiguchi, K., Nakayama, K., Nakayama, T., Okamura, T., Okamura, S., Niho, Y., Nakayama, K.I.; Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function. Immunity 13, 561-571 (2000).
- Kitagawa, K., Kawamoto, T., Kunugita, N., Tsukiyama, T., Okamoto, K., Yoshida, A., Nakayama, K., Nakayama, K.I.; Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse. FEBS Lett. 476, 306-311 (2000).
- Takai, H., Tominaga, K., Motoyama, N., Minamishima, Y.A., Nagahama, H., Tsukiyama, T., Ikeda, K., Nakayama, K., Nakanishi, N., Nakayama, K.I.; Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice. Genes. Dev. 14, 1439-1447 (2000).
- Nakayama, K., Nagahama, H., Minamishima, Y.A., Matsumoto, M., Nakamichi, I., Kitagawa, K., Shirane, M., Tsunematsu, R., Tsukiyama, T., Ishida, N., Kitagawa, M., Nakayama, K.I., Hatakeyama, S.; Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J. 19, 2069-2081 (2000).
- Takahashi, K., Nakayama, K.I., Nakayama, K.; Mice lacking a CDK inhibitor, p57(Kip2), exhibit skeletal abnormalities and growth retardation. J. Biochem. 127, 73-83 (2000).
- Ishida, N., Kitagawa, M., Hatakeyama, S., Nakayama, K.I.; Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability. J. Biol. Chem. 275, 25146-54 (2000).
- Ishida, K.I., Ishida, N., Hara, Y.; Lotharella amoeboformis sp. nov.: a new species of chlorarachniophytes from Japan. Phycol. Res. 48, 221-9 (2000).
1999年
- Shirane, M., Hatakeyama, S., Hattori, K., Nakayama, K., Nakayama, K.I.; Common pathway for the ubiquitination of I kappa B alpha, I kappa B beta, and I kappa B epsilon mediated by the F-box protein FWD1. J. Biol. Chem. 274, 28169-28174 (1999).
- Kitagawa, M., Hatakeyama, S., Shirane, M., Matsumoto, M., Ishida, N., Hattori, K., Nakamichi, I., Kikuchi, A., Nakayama, K.I., Nakayama, K.; An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin. EMBO J. 18, 2401-10 (1999).
- Hatakeyama, S., Kitagawa, M., Nakayama, K., Shirane, M., Matsumoto, M., Hattori, K., Higashi, H., Nakano, H., Okumura, K., Onoe, K., Good, R. A., Nakayama, K.I.; Ubiquitin-dependent degradation of I kappa B alpha is mediated by a ubiquitin ligase Skp1/Cul1/F-box protein FWD1. Proc. Natl. Acad. Sci. U S A 96, 3859-3863 (1999).
1998年
- Hamasaki, A., Sendo, F., Nakayama, K., Ishida, N., Negishi, I., Nakayama, K.I., Hatakeyama, S.; Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene. J. Exp. Med. 188, 1985-1992 (1998).
- Hatakeyama, S., Hamasaki, A., Negishi, I., Loh, D. Y., Sendo, F., Nakayama, K., Nakayama, K.I.; Multiple gene duplication and expression of mouse bcl-2-related genes, A1. Int. Immunol. 10, 631-637 (1998)
1997年
- Matsuzaki, Y., Nakayama, K.I., Nakayama, K., Tomita, T., Isoda, M., Loh, D. Y., Nakauchi, H.; Role of bcl-2 in the development of lymphoid cells from the hematopoietic stem cell. Blood 89, 853-62 (1997).
1996年
- Nagata, M., Nakauchi, H., Nakayama, K.I., Nakayama, K., Loh, D., Watanabe, T.; Apoptosis during an early stage of nephrogenesis induces renal hypoplasia in bcl-2-deficient mice. Am. J. Pathol. 148, 1601-11 (1996).
- Senju, S., Negishi, I., Motoyama, N., Wang, F., Nakayama, K.I., Nakayama, K., Lucas, P.J., Hatakeyama, S., Zhang, Q., Yonehara, S., Loh, D.Y.; Functional significance of the Fas molecule in naive lymphocytes. Int. Immunol. 8, 423-31 (1996).
- Nakayama, K., Ishida, N., Shirane, M., Inomata, A., Inoue, T., Shishido, N., Horii, I., Loh, D.Y., Nakayama, K.I.; Mice lacking p27Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 85, 707-20 (1996).
1995年
- Nakayama, K.I., Nakayama, K., Dustin, L.B., Loh, D.Y.; T-B cell interaction inhibits spontaneous apoptosis of mature lymphocytes in Bcl-2-deficient mice. J. Exp. Med. 182, 1101-9 (1995).
- Merritt, A.J., Potten, C.S., Watson, A.J., Loh, D.Y., Nakayama, K.I., Nakayama, K., Hickman, J. A.; Differential expression of bcl-2 in intestinal epithelia. Correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia. J. Cell. Sci. 108, 2261-71 (1995).
- Negishi, I., Motoyama, N., Nakayama, K.I., Nakayama, K., Senju, S., Hatakeyama, S., Zhang, Q., Chan, A.C., Loh, D.Y.; Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature 376, 435-8 (1995).
- Motoyama, N., Wang, F., Roth, K. A., Sawa, H., Nakayama, K.I., Nakayama, K., Negishi, I., Senju, S., Zhang, Q., Fujii, S., Loh, D.Y.; Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science 267, 1506-10 (1995).
1994年
- Nakayama, K., Nakayama, K.I., Negishi, I., Kuida, K., Sawa, H., Loh, D.Y.; Targeted disruption of Bcl-2 ab in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia. Proc. Natl. Acad. Sci. U S A 91, 3700-4 (1994).
- Nakayama, K.I., Nakayama, K., Negishi, I., Kuida, K., Louie, M.C., Kanagawa, O., Nakauchi, H., Loh, D.Y.; Requirement for CD8 b chain in positive selection of CD8-lineage T cells. Science 263, 1131-3 (1994).
1993年
- Nakayama, K.I., Nakayama, K., Negishi, I., Kuida, K., Shinkai, Y., Louie, M.C., Fields, L.E., Lucas, P.J., Stewart, V., Alt, F.W., Loh, D.Y.; Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice. Science 261, 1584-8 (1993).
- Hiraoka, M., Fan, Z., Furukawa, T., Nakayama, K., Sawanobori, T.; Activation and reactivation of the ATP-sensitive K+ channel of the heart can be modified by drugs. Cardiovasc. Drugs. Ther. 7, 593-8 (1993).
1992年
- Fan, Z., Nakayama, K., Sawanobori, T., Hiraoka, M.; Aromatic aldehydes and aromatic ketones open ATP-sensitive K+ channels in guinea-pig ventricular myocytes. Pflugers Arch. 421, 409-15 (1992).
1991年
- Nakayama, K., Fan, Z., Marumo, F., Sawanobori, T., Hiraoka, M.; Action of nicorandil on ATP-sensitive K+ channel in guinea-pig ventricular myocytes. Br. J. Pharmacol. 103, 1641-8 (1991).
1990年
- Fan, Z., Nakayama, K., Hiraoka, M.; Multiple actions of pinacidil on adenosine triphosphate-sensitive potassium channels in guinea-pig ventricular myocytes. J. Physiol. (Lond.) 430, 273-95 (1990).
- Nakayama, K., Fan, Z., Marumo, F., Hiraoka, M.; Interrelation between pinacidil and intracellular ATP concentrations on activation of the ATP-sensitive K+ current in guinea pig ventricular myocytes. Circ. Res. 67, 1124-33 (1990).
- Fan, Z., Nakayama, K., Hiraoka, M.; Pinacidil activates the ATP-sensitive K+ channel in inside-out and cell-attached patch membranes of guinea-pig ventricular myocytes. Pflugers Arch. 415, 387-94 (1990).