トップ > メンバー > 中川 直

メンバー

中川 直

助教
1979年生まれ
北海道恵庭市出身

略歴

2008.3 九州大学大学院医学系学府 博士課程修了 (医学博士)
2008.4〜2013.3 ノースカロライナ大学ラインバーガーがん研究所 ポスドク
2013.4〜 東北大学大学院医学系研究科附属創生応用医学研究センター
がん医学コアセンター 細胞増殖制御分野 助教

現在の研究テーマ

ユビキチン-プロテアソーム系によるクロマチン制御機構

実績

Nakagawa, T., Nakayama, K., Nakayam, KI. Knockout Mouse Models Provide Insight into the Biological Functions of CRL1 Components. Adv Exp Med Biol 1217, 147-171 (2020)

Nakagawa, T., Hosogane, M., Nakagawa, M., Morohoshi, A., Funayama, R., Nakayama, K. Transforming Growth Factor β-Induced Proliferative Arrest Mediated by TRIM26-Dependent TAF7 Degradation and Its Antagonism by MYC. Mol Cell Biol38, pii: e00449-17 (2018).

Nakagawa, T., Zhang, T., Kushi, R., Nakano, S., Endo, T., Nakagawa, M., Yanagihara, N., Zarkower. D., Nakayama. K. Regulation of mitosis-meiosis transition by the ubiquitin ligase beta-TrCP in male germ cells. Development 144, 4137-4147 (2017).

Nakagawa, T., Araki, T., Nakagawa, M., Hirao, A., Unno, M. & Nakayama, K. S6 Kinase- and beta-TrCP2-Dependent Degradation of p19Arf Is Required for Cell Proliferation. Mol Cell Biol 35, 3517-3527 (2015).

Nakagawa, T. & Nakayama, K. Protein monoubiquitylation: targets and diverse functions. Genes Cells 20, 543-562 (2015).

Nakagawa, T., Lv, L., Nakagawa, M., Yu, Y., Yu, C., D'Alessio, A. C., Nakayama, K., Fan, H. Y., Chen, X. & Xiong, Y. CRL4(VprBP) E3 Ligase Promotes Monoubiquitylation and Chromatin Binding of TET Dioxygenases. Mol Cell 57, 247-260 (2015).

Vulto-van Silfhout, A. T., Nakagawa, T., Bahi-Buisson, N., Haas, S. A., Hu, H., Bienek, M., Vissers, L. E., Gilissen, C., Tzschach, A., Busche, A., Musebeck, J., Rump, P., Mathijssen, I. B., Avela, K., Somer, M., Doagu, F., Philips, A. K., Rauch, A., Baumer, A., Voesenek, K., Poirier, K., Vigneron, J., Amram, D., Odent, S., Nawara, M., Obersztyn, E., Lenart, J., Charzewska, A., Lebrun, N., Fischer, U., Nillesen, W. M., Yntema, H. G., Jarvela, I., Ropers, H. H., de Vries, B. B., Brunner, H. G., van Bokhoven, H., Raymond, F. L., Willemsen, M. A., Chelly, J., Xiong, Y., Barkovich, A. J., Kalscheuer, V. M., Kleefstra, T. & de Brouwer, A. P. Variants in CUL4B are Associated with Cerebral Malformations. Hum Mutat 36, 106-117 (2015).

Nakagawa T, Mondal K, Swanson PC. (2013) VprBP (DCAF1): a promiscuous substrate recognition subunit that incorporates into both RING-family CRL4 and HECT-family EDD/UBR5 E3 ubiquitin ligases. BMC Mol Biol. 13;14:22.

Nakagawa T, Xiong Y. (2011) X-linked mental retardation gene product CUL4B targets ubiquitylation of H3K4 methyltransferase component WDR5 and regulates neuronal gene expression. Mol. Cell 43: 381-91

Kotake Y, Nakagawa T, Kitagawa K, Suzuki S, Lin N, Kitagawa M, Xiong Y. (2011) Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15 (INK4B) tumor suppressor gene. Oncogene 30: 1956-62

Nishiyama M, Oshikawa K, Tsukada Y, Nakagawa T, Iemura S, Natsume T, Fan Y, Kikuchi A, Skoultchi AI, Nakayama KI. (2009) CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis. Nat Cell Biol. 11: 172-82

Nakagawa T, Tsuruma K, Uehara T, Nomura Y. (2008) GMEB1, a novel endogenous caspase inhibitor, prevents hypoxia- and oxidative stress-induced neuronal apoptosis. Neurosci Lett. 438: 34-7

Nakagawa T, Shirane M, Iemura S, Natsume T, Nakayama KI. (2007) Anchoring of the 26S Proteasome to the Organellar Membrane by FKBP38. Genes Cells. 12: 709-719

Fujii Y, Yada M, Nishiyama M, Kamura T, Takahashi H, Tsunematsu R, Susaki E, Nakagawa T, Matsumoto A, Nakayama KI (2006) Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin-dependent degradation. Cancer Sci. 97: 729-736

Tsuruma K, Nakagawa T, Morimoto N, Minami M, Hara H, Uehara T, Nomura Y. (2006) Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury. J.Biol.Chem. 281: 11397-11404

Kaneko-Oshikawa C*, Nakagawa T*, Yamada M, Yoshikawa H, Matsumoto M, Yada M, Hatakeyama S, Nakayama K, Nakayama KI. (2005) *equally contributed authors Mammalian E4 is required for cardiac development and maintenance of the nervous system. Mol.Cell.Biol. 25: 10953-10964

Tsuruma K, Nakagawa T, Shirakura H, Hayashi N, Uehara T, Nomura Y. (2004) Regulation of procaspase-2 by glucocorticoid modulatory element-binding protein 1 through the interaction with caspase recruitment domain. Biochem. Biophys. Res. Commun. 325: 1246-1251

趣味

実験、論文読み(理解できるものに限る)

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北海道、九州、アメリカと渡り歩き、本州初上陸です。
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